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KMID : 0381219960280020062
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Journal of RIMSK
1996 Volume.28 No. 2 p.62 ~ p.70
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Histologic Changes Following Ballon Injury to the Rat Carotid Artery
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김철우
정유석/이광제/곽미향/김경만/김치정/류왕성/유언호/김미경
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Abstract
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Coronary angioplasty has been limited by a 30~40% incidence of restenosis, typically developing within 3~6 months of the procedure However, the pathophysioloic mechanism responsible for this problem still poorly understood. The development of
luminal
narrowing in relationship to intimal thickening was investigated in rat common carotid artery denuded of endothelium. With a modified balloon catheter the endothelium of rat common carotid artery was completely removed to study the morphologic
change of
the vessel wall to intimal injury. Endothelial regeneration and formation of an intimal fibrocellular thickening Proliferating cells appeared in the intima only in areas which were not covered by regenerating endothelium 7 days after injury At 2
weeks
there was an apparent increase in cell number. Subsequently, the intima became thicker in a symmetrical manner with respect to the long axis, achieving a maximum around 4 weeks. At late time points, the cell density was reduced in the intima away
from
the luminal surface. In summary, these results show that balloon injury markedly induces cellular proliferation and continued intimal thickening seems to be due to synthesis and accumulation of connective tissue.
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KEYWORD
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